Saturday, February 9, 2013

The sound of N.Y. Fashion Week: Smartphones snapping

NEW YORK (AP) ? Remember clapping? As in when a fashion designer puts on his runway finale and then takes a bow before an adoring crowd.

The fashion hordes these days are way too busy tweeting, Instagramming and taking video with their smartphones to put those busy hands together. But more often than not, so are the fashion houses.

Technology has taken over in important ways for designers and was ready made for this New York Fashion Week as the huge storm had the elite teetering around Manhattan in blowing snow, clutching those phones.

Audiences had already been on the bandwagon, taking phone pics from their seats and posting reviews online before the models were off the runway, but designers are figuring out how to use all the instant feedback to their advantage.

Before the snow hit, information went out to retailers, editors, stylists and bloggers on how to view the Donna Karan and Helmut Lang shows online and through phone apps for those unable to attend in person.

Rachel Roy and Peter Som switched to entirely digital catwalk shows. Rebecca Minkoff and Kenneth Cole beamed live tweets on the walls, with Cole pledging donations to amFAR if a certain hashtag was used during the show.

Tommy Hilfiger collected curated interactions ? and added some himself ? that were shared with guests entering and exiting his menswear show. He planned to do the same Sunday for his women's collection.

Still clutching those phones, the crowds dealt Saturday ? Day 3 of the eight days of fall previews ? with the storm's mush of an aftermath in their dash around town and at the Mercedes-Benz Fashion Week tents at Lincoln Center.

The industry will shift to Milan, London and then Paris after the shows close here Feb. 14.

PRABAL GURUNG

Military touches are shorthand in high fashion for strength and confidence. Gurung added some exclamation points, specifically citing as his muse a woman in combat.

There has been much in the news ? and Gurung is a newshound ? about the Pentagon's decision to open more on-the-ground options to women and also technological advances in women's body armor.

"They're redesigning the whole uniform for women because all this while they've been wearing men's uniform," he said backstage.

That led Gurung to think about women's empowerment, all the way to women he read about from the Ukraine who are coming together in self-defense against human trafficking.

There were smart jackets with gold hardware and some with red-and-black brocades, crisp navy suits, and leather harnesses over stretch-crepe dresses with sexy slashes on the bodice and asymmetric peplums and hemlines.

There had to be a little femininity mixed in with the aggressiveness, Gurung explained, because it's femininity that gives women their best tool "to rule a man's world."

JILL STUART

It was that easy: Stuart woke up one day thinking about how stylish British model Stella Tennant and her friends were, so Stuart thought she would create a wardrobe just for them.

She aimed to dress an aristocratic fashion risk-taker for all those parties at castles in the English countryside.

"I was thinking about the beautiful dinners and the charades she and her friends play, and the great performances they see at the end of the night," Stuart said backstage.

Her offerings include a plum-colored halter dress covered in satin flowers, a more tailored dress in black wool with more sharply cut flowers, and a white sheer man-tailored shirt paired with black evening shorts and a full-cut long black coat.

NICOLE MILLER

Miller's collection was called "Menswear With a Twist: Raiding the Boyfriend's Closet."

It was the good girl meets bad boy, packing a wardrobe of tough leather jackets, pleated skirts and several fedoras for the adventure. No apologies to mom.

There were particularly short knit dresses and a skin-hugging corset dress in a print called "tatooage," which looked exactly as it sounds.

And there were outfits more in line with what's expected from Miller, including a long dress in a wallflower print with a ruffle front and a stretch-denim dress with sexy net inserts.

The black matte-jersey, floor-length dress, with a dropped leather waist and notched V neck, that closed the show was the right high note to leave on.

But where Miller saw "golf pants" on a pair of loose baggy trousers paired with a burned out velvet-and-georgette blouse, the audience might have seen glorified sweats.

REBECCA MINKOFF

Minkoff named her colors after planets and other spacey things.

A winter white was "Saturn" and used for a leather motocross jacket. The color caramel became "eclipse" for a leather duffel coat.

Minkoff put a twist on the colorblocking trend that has been around now a few seasons by mixing chunks of different textures instead of contrasting hues. That technique was also seen on the runways of Jason Wu and Nicole Miller.

Minkoff's soft-line exaggerated shoulder, instead of the aggressive ones that were so popular on the runways a few years ago (and in the 1980s), also turned up elsewhere.

The collection "embarks on a voyage to the future, marrying modern, spacesuit-like construction details and a new sophisticated grunge attitude," Minkoff wrote in her notes.

___

Follow Samantha Critchell on Twitter at http://twitter.com/AP_Fashion

Source: http://news.yahoo.com/sound-ny-fashion-week-smartphones-snapping-213911932.html

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Snowstorm forces rescheduling of Bruins-TB game

BOSTON (AP) ? The Boston Bruins have postponed Saturday night's game against the Tampa Bay Lightning because of the blizzard that dumped more than 2 feet of snow on the area.

No makeup date had been scheduled yet, according to a Bruins spokesman.

Originally scheduled for 1 p.m., the game was pushed back until 7 p.m. to allow the storm to pass. But public transportation was not expected to resume on Saturday, and roads were still being cleared. A travel ban was in effect until 4 p.m.

The Bruins already are playing an abbreviated schedule because of the lockout that wiped out the first 3? months of the season.

Source: http://news.yahoo.com/snowstorm-forces-rescheduling-bruins-tb-game-202314619--nhl.html

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Friday, February 8, 2013

Red Frog Blog ? Blog Archive ? Want To Make Home Improvements ...

We see the very same scenery every single single day in our homes, and that is why so a lot of homeowners choose that it really is time for a tiny remodeling. Painting the walls, rearranging the furniture, and going with new molding ? these can look like simple sufficient tasks from the start off. However, numerous men and women locate that they?re daunting. No matter what your ambitions are, verify out these home- improvement guidelines.

Set up huge corner shelves in your bedroom just under the ceiling. These shelves can easily be constructed employing just a sheet of plywood and a couple of pieces of molding. Reduce the shelf large enough that it can be used to hold massive comforters and other things that you need to have to hold up and out of the way.

You need to do a simple internet search if you are hunting for basic contractors in your area. A lot of contractors are now posting ads on the internet to help enhance their company. You can uncover a contractor that fits your wants and even reads testimonials from their earlier consumers. This is a swift and easy way to uncover a contractor to do your home improvement job.

Before you start off painting a wall, you have to prep the surface. Prepping the wall requires washing it with soap and water, which removes built-up dirt and grease that can have an effect on how the paint sticks to your wall. A dirty wall will result in paint to chip sooner, shortening the life of your paint job.

Freshen up the appear of your aging bathroom with no re-tiling. Scrape any accumulated grout, and then re-grout alternatively of replacing the tile. Buff out any leftover haze to make it appear sparkling and new. Add new light fixtures, a medicine cabinet, shower doors or a fancy faucet for added effect.

Give any room a new appear simply by changing the window treatment options. Curtains are inexpensive, and you can modify the character of your room by picking fabrics in the acceptable patterns. You can even customize the look by season by deciding on fabrics in colors that reflect the seasons, such as light colors for spring and summer time, and richer colors for autumn and winter.

If you?re performing home improvements to aid the sale of a home, you have to concentrate on aesthetics, but you need to also have a property inspection, just in case one thing serious needs to be completed, as well. If you can install a new roof or furnace, it will show the buyers that you had been on prime of your game and will permit you to command a larger price.

Prior to painting, stripping wallpaper, or performing other updates to your walls, get rid of all of the outlet covers and switchplates from the room in which you are functioning. This ensures that the covers remain cost-free of paint splatters, and when you reinstall them more than the painted surface, the benefits will be seamless.

To correctly stain your deck yourself, be positive that you use the proper tools to do so beginning with the brushes you use to apply the stain. If you pick a oil based stain, a organic bristle brush is the way to go. When using a stain that is water primarily based use a brush with nylon bristles.

When thinking about a bathroom remodel, think small. A small budget can nevertheless mean a massive impact, that looks much much more expensive than it truly was. Replace towel bars, toilet roll holders, the mirror, and your light fixture. Add a coat of paint to genuinely spruce things up. Your bathroom will look modern and updated without leaving a dent in your pocketbook.

A excellent way to lessen your chance of mold development in your household is by making certain your bathroom is nicely ventilated. Bathrooms that do not have a window or some sort of vent normally get steamy, but are unable to be rid of the humidity. Sooner or later this humidity contributes to in depth mold development.

Something that seems on the surface to be so simple can end up getting incredibly complex if you happen to be not aware of how to manage a job. Painting can turn into a nightmare adding a lot more lights could leave you in the dark. The suggestions in this report will help you learn about property improvement, so put them to excellent use. your manassas hvac

Source: http://www.getyourfrogon.com/blog/?p=731

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Lucy Lawless says trespass ruling 'great victory'

FILE - In this Feb. 27, 2012 file photo provided by Greenpeace, actress Lucy Lawless, third from left, speaks along with Greenpeace activists, from left, Raoni Hammer, Vivienne Hadlow and Shai Naides, outside the central police station in New Plymouth, New Zealand, after their release on bail on charges relating to protesting aboard Arctic oil-drilling ship, the Noble Discoverer, in Port Taranaki. Lawless says she's won a "great victory" after a New Zealand judge handed her a modest sentence but declined to order costs sought by oil company Shell for her role in a protest aboard the oil-drilling ship. Lawless and seven other Greenpeace activists were each ordered Thursday, Feb. 7, 2013 to pay 651 New Zealand dollars ($547) costs to a port company and complete 120 hours of community service after earlier pleading guilty to trespass charges. (AP Photo/Greenpeace, Nigel Marple, File) NO SALES, EDITORIAL USE ONLY, MANDATORY CREDIT

FILE - In this Feb. 27, 2012 file photo provided by Greenpeace, actress Lucy Lawless, third from left, speaks along with Greenpeace activists, from left, Raoni Hammer, Vivienne Hadlow and Shai Naides, outside the central police station in New Plymouth, New Zealand, after their release on bail on charges relating to protesting aboard Arctic oil-drilling ship, the Noble Discoverer, in Port Taranaki. Lawless says she's won a "great victory" after a New Zealand judge handed her a modest sentence but declined to order costs sought by oil company Shell for her role in a protest aboard the oil-drilling ship. Lawless and seven other Greenpeace activists were each ordered Thursday, Feb. 7, 2013 to pay 651 New Zealand dollars ($547) costs to a port company and complete 120 hours of community service after earlier pleading guilty to trespass charges. (AP Photo/Greenpeace, Nigel Marple, File) NO SALES, EDITORIAL USE ONLY, MANDATORY CREDIT

(AP) ? "Xena: Warrior Princess" actor Lucy Lawless says she's won a "great victory" after a New Zealand judge handed her a modest sentence but declined to order costs sought by oil company Shell for her role in a protest aboard an oil-drilling ship.

Lawless and seven other Greenpeace activists were each ordered Thursday to pay 651 New Zealand dollars ($547) costs to a port company and complete 120 hours of community service after earlier pleading guilty to trespass charges.

Last February, Lawless and six other activists climbed a drilling tower on the Arctic-bound vessel Noble Discoverer to protest oil exploration in the Arctic. Another protester helped from the ground. Lawless spent four days atop the 174-foot (53-meter) tower, camping and blogging about her experiences. The action briefly delayed the ship's voyage.

Shell Todd Oil Services, which had chartered the ship, sought about 650,000 New Zealand dollars ($545,000) in reparations from the protesters.

Lawyers for the activists contended that amount was excessive. In his ruling, Judge Allan Roberts said the company could pursue its claim through the civil court system.

Shell Todd declined to comment on whether it would pursue civil action. In a statement, the company said it has "always supported the efforts of law enforcement to respond to this incident and to deter such activity in the future."

Lawless is best known for her title role in "Xena" and more recently for starring in the Starz cable television series "Spartacus."

"I consider it a great victory that the court has struck down the reparation demand from Shell, which I think was absolutely ludicrous," Lawless said.

She said she was happy to clean toilets, pick up litter or do whatever else was required for her community service and that she has no regrets about taking part in the protest, which she said has helped highlight concerns about oil exploration in the Arctic.

Greenpeace says more than 2 million people have signed its petition to make the Arctic a sanctuary and off-limits for oil exploration.

Lawless said she plans to continue protesting against climate change and oil drilling.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/4e67281c3f754d0696fbfdee0f3f1469/Article_2013-02-06-New%20Zealand-Lucy%20Lawless/id-03ecf8bb866a41f5963ecf97316e9cf1

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Video Interviews with the Cast of Side Effects: Jude Law, Channing Tatum, Rooney Mara, and more

Luke Goodsell is committed to not revealing too much about Steven Soderbergh's new movie Side Effects for your benefit. He manages to discuss it with Channing Tatum, Rooney Mara, Jude Law, and Vinessa Shaw without ruining anything for you. Plus, see the cast's plea to Steven Soderbergh that turns into a full-fledged thing by the end.

Click here to watch more video interviews

Source: http://www.rottentomatoes.com/m/1926813/news/1926813/

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Twitter simplifies search for Android, iOS and mobile web users

DNP Twitter steps its search game up with new updates for Android, iOS and mobile web

Today, Twitter announced an update for its search features for Android, iOS and mobile web. Furthering the company's efforts for a more uniform user experience, the new updated adds a search button to the iPhone app, bringing it up to speed with its Android and iPad counterparts. Across the board users will be treated to improved search results for photos, tweets and accounts, along with a preview section for the Discover tab that takes a peek at the latest trends and activity. Wondering how all this magic works? Twitter's Engineering blog describes the process by which pieces of content are ranked and scored based on factors like "burstiness" to account for recent interest spikes.

As for the Connect tab, it now defaults to Interactions, which displays new followers, mentions and retweets. However, if you're not looking to keep track of who quoted your recent product placement rant, you can change your settings to Mentions only. Finally, and perhaps our most favorite new addition is a change to how Twitter's mobile implementations handle links. You can now click a URL directly from your timeline without having to open the related tweet. The mobile site is already sporting the latest updates, but you'll need to update your iOS and Android (it's a manual update, thanks to a change in permissions) apps at their respective stores.

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Via: TechCrunch

Source: Twitter, Twitter Engineering blog

Source: http://www.engadget.com/2013/02/06/twitter-search-updated-android-ios-web/

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Thursday, February 7, 2013

Study points to possible cause of, and treatment for, non-familial Parkinson's

Thursday, February 7, 2013

Columbia University Medical Center (CUMC) researchers have identified a protein trafficking defect within brain cells that may underlie common non-familial forms of Parkinson's disease. The defect is at a point of convergence for the action of at least three different genes that had been implicated in prior studies of Parkinson's disease. Whereas most molecular studies focus on mutations associated with rare familial forms of the disease, these findings relate directly to the common non-familial form of Parkinson's. The study was published today in the online edition of the journal Neuron.

The defective pathway is called the "retromer" pathway, in part because it can guide the reutilization of key molecules by moving them back from the cell surface to internal stores. In this study, defects in the retromer pathway also appear to have profound effects on the cell's disposal machinery, which may explain why Parkinson's disease brain cells ultimately accumulate large protein aggregates. The trafficking defects associated with Parkinson's can be reversed by increasing retromer pathway activity, suggesting a possible therapeutic strategy. No current therapies for Parkinson's alter the progression of the disease.

The researchers also found evidence that, even in unaffected individuals who simply carry common genetic variants associated with an increased risk of Parkinson's disease, these molecular changes are at work. This supports the notion that early treatment approaches will be important in tackling Parkinson's disease.

"Taken together, the findings suggest that drugs that target the retromer pathway could help prevent or treat Parkinson's," said study leader Asa Abeliovich, MD, PhD, associate professor of pathology and cell biology and of neurology in the Taub Institute for Research on Alzheimer's Disease and the Aging Brain at CUMC.

In recent years, through genome-wide association studies (GWAS), researchers have identified about 10 common genetic variants that appear to have small effects on the risk of non-familial Parkinson's, However, it has been hard to delve deeper into the impact of these variants. "When you look at patient brain tissue at autopsy, it's usually too late ? all the critical dopamine neurons are long gone and the damage has been done," said Dr. Abeliovich.

In the current study, Dr. Abeliovich and his CUMC colleagues used an unusually broad array of approaches ? including analyses of Parkinson's disease-associated genetic variations, patient brain tissue, in vitro tissue culture studies of brain neurons, and fruit fly (Drosophila) models that harbor genetic variants related to those associated with Parkinson's disease.

The researchers found that common variants in two genes previously linked to Parkinson's disease, LRRK2 and RAB7L1, led to an unexpectedly similar impact on human brain tissue. The effects of the variants were found to be highly overlapping, pointing to a common pathway of action. Prominent cellular changes were observed in the retromer pathway, which is involved in the trafficking of proteins from the Golgi apparatus (which packages proteins for delivery to other cell components) to the lysosomes (which recycle proteins and other molecules). Mutations that affect the retromer pathway have also been found in familial Parkinson's disease. Earlier studies from CUMC's Taub Institute have shown that genetic variants in genes associated with retromer function are linked to Alzheimer's disease and retromer component levels appear altered in Alzheimer's disease brains, suggesting a broader role for retromer dysfunction in neurodegenerative diseases of aging, according to Dr. Abeliovich.

The impact of the RAB7L1 and LRRK2 variants was apparent even in individuals with no signs or symptoms of Parkinson's disease. This suggests that there is a pre-disease state in unaffected carriers of the two genetic variants that favors early disease onset and that, in theory, could be targeted therapeutically.

The CUMC researchers also demonstrated that overexpression of one of the variants, RAB7L1, can overcome the effects of the other variant. Similarly, expression of VPS35, a gene involved in the retromer pathway, can suppress LRRK2 mutant pathology. "It will be interesting to look for drugs that directly target these retromer components or that more generally promote flow through the pathway," said Dr. Abeliovich.

###

The title of the paper is "RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk." The other contributors are David A. Macleod, Herve Rhinn, Tomoki Kuwahara, Ari Zolin, Gilbert Di Paolo, Brian D. McCabe, Lorraine N. Clark, and Scott A. Small, all at CUMC.

Columbia University Medical Center: http://www.cumc.columbia.edu

Thanks to Columbia University Medical Center for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/126674/Study_points_to_possible_cause_of__and_treatment_for__non_familial_Parkinson_s

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